Psychiatry

PGx testing linked to faster symptom improvement in hospitalized SCZ, MDD, and BD patients.

In a retrospective cohort of 3,942 psychiatric inpatients, PGx-tested patients improved faster on disorder-specific scales than usual care. Linear mixed models showed significant negative PGx-by-time interactions for PANSS, HAMD/HAMA, and YMRS/HAMD scores. PGx patients had more severe baseline symptoms and higher hospital costs, and MDD patients had longer stays. As an observational real-world study, results suggest PGx may speed symptomatic response but cannot prove causality. 1

Umbrella review: MBSR favored for anxiety in lung cancer but overall evidence very low.

Across 82 meta-analyses (113 estimates), most outcomes in cancer patients had very low GRADE certainty. Mindfulness-based stress reduction outperformed standard treatment for anxiety in lung cancer (Hedges'g = -1.46). Psychotherapy after mastectomy often performed worse than waiting list for anxiety related to body image. Overall, evidence is limited; MBSR is a reasonable option when available, but stronger trials are needed. 2

QoL and PROMs in Saudi psychiatric pharmacotherapy are heterogeneously measured.

The systematic review included 10 studies and 3,773 patients using 15 different QoL/PROM instruments. One-third of studies used the Morisky Medication Adherence Scale and reported low-to-moderate adherence. Heterogeneous measures limit comparability and signal the need for standardized PROMs and adherence-focused interventions. Clinicians should prioritize validated, consistent QoL tools and interventions to improve medication adherence reporting. 3