Urology

Patient-perpetrated sexual harassment is common and sex-discordant in US urology workforce

In a 1,467-clinician cohort from the AUA census, 17.9% reported experiencing patient-perpetrated sexual harassment and 29.6% witnessed it. Female clinicians experienced harassment far more often than males (41.8% vs 6.3%). Trainees and APPs reported higher unadjusted rates than practicing urologists, but adjusted odds were lower for trainees (aOR 0.51) and APPs (aOR 0.34). Most harassment occurred in clinic settings, and while ~67% knew of formal reporting processes, many were unaware whether patients were notified. 1

ARNI therapy in heart failure linked to smaller renal declines depending on endpoint definition

Meta-analysis of 34,969 patients found sacubitril/valsartan reduced sustained ≥50% eGFR decline (RR 0.68) and composite kidney outcomes (RR 0.70). End-stage kidney disease alone trended favorable but was borderline significant (RR 0.80; CI includes 1.00). ARNI use was associated with a slower annualized eGFR decline (MD 0.52 mL/min/1.73 m2/year). Authors caution the renal signal varies with endpoint choice, so findings are hypothesis-generating for nephroprotection. 2

Expert MRI reading and higher image quality improve clinically significant prostate cancer detection

In 516 men from the PROBASE screening substudy, reference expert reading had higher sensitivity (83% vs 69%) and NPV (92% vs 86%) versus local reads. Reference reading reduced false positives in PI-RADS 4–5 and missed far fewer csPCa in PI-RADS 1–2. Lower MRI quality (PI-QUAL 1–3) was associated with lower csPCa detection (46% vs 62%) and lower true-negative rates. The study supports using standardized high-quality imaging and experienced readers in MRI-based screening programs. 3