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Grand RoundsWeekly Evidence Brief

Trauma Surgery

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30-Second Takeaway

  • New persistent opioid use after surgery affects roughly **7%** of opioid‑naïve US adults prescribed postoperative opioids.
  • Outcome definitions for prosthetic joint infection are heterogeneous; a consensus core outcome set is needed.

Latest - Week ending July 4, 2026

Concise evidence briefs for surgical practice from recent systematic, cohort, and qualitative studies

New persistent opioid use occurs in about 7% of opioid‑naïve surgical patients in the USA.

REGIONAL ANESTHESIA AND PAIN MEDICINEJun 27, 2026

This meta‑analysis pooled 43 observational studies (n=6,507,173) and estimated a pooled NPOU incidence of 7.15% (95% CI 6.02–8.38). Heterogeneity was very high (I2=100%) with a 95% prediction interval of 1.34%–17.02%, reflecting definition and study differences. Studies using a 90–180 day definition reported higher incidence (8.29%) than stricter 180‑day definitions (2.89%). Implication: consider protocolized opioid minimization and follow-up for persistent use after discharge.

Timing of surgical stabilization of rib fractures compared with nonoperative care—respiratory outcomes reported.

JAMA SURGERYJul 1, 2026

This cohort study compared early, intermediate, and late surgical rib fixation versus nonoperative management for blunt chest trauma. The abstract reports respiratory outcomes but does not provide effect sizes or adjusted estimates for timing comparisons. Implication: with timing studies vulnerable to selection bias, wait for detailed adjusted results before changing practice. Consider individualizing fixation timing based on respiratory trajectory, pain control, and physiologic reserve.

PJI outcome reporting is highly heterogeneous; a working core outcome set is proposed.

OPEN FORUM INFECTIOUS DISEASESJul 2, 2026

This meta‑epidemiologic review included 461 studies and found major heterogeneity in PJI outcome definitions across seven domains. Most studies were retrospective (416/461) with few RCTs (8) and limited use of patient‑reported outcome measures (111 studies). The authors propose a working core outcome set to harmonize reporting and improve comparability for future research. Implication: adopt standardized outcome sets in PJI research and include PROMs when feasible for patient‑centered assessment.

References

Numbered in order of appearance. Click any reference to view details.

Additional Reads

Optional additional studies from this edition.

Edition context

Clinical signal

  • Monitor for persistent opioid use after discharge and prioritize nonopioid analgesia and prescription minimization.
  • When reading PJI literature, check which outcome domains are used before applying results to care decisions.
  • Be cautious applying timing results from rib fixation cohorts until effect sizes and confounder adjustment are reported.