Sleep Medicine

Chronic spontaneous urticaria commonly disrupts sleep and relates to disease activity

Across heterogeneous cohorts, patients with chronic spontaneous urticaria (CSU) had worse global sleep quality and greater insomnia severity than controls. CSU was associated with shorter sleep duration, longer sleep latency, and correlations with higher UAS7 disease activity and worse quality of life. Emerging biomarker signals suggest circadian-immune dysregulation and some cohorts showed increased obstructive sleep apnea risk. Evidence is largely cross-sectional and variable by study method, but supports routine sleep assessment in CSU management. 1

Light exposure patterns associate with symptom severity and biomarkers in ME/CFS

In 100 ME/CFS patients and 56 controls monitored by wrist actigraphy, two light-pattern components explained most variance: daytime stability (PC1) and nocturnal/early-morning light with rhythm instability (PC2). Higher PC1 (more daytime light, stable rhythms) linked to lower fatigue, better sleep scores, and improved quality of life in ME/CFS. Higher PC2 associated with higher VCAM-1 and triglycerides and lower serotonin concentrations in patients. Cross-sectional design prevents causal inference, but behavioral light interventions are plausible low-risk options to trial. 2

rTMS often improves self-reported sleep in adults with substance use disorders

Systematic review of 12 studies found that 10 reported statistically significant self-reported sleep improvements after rTMS in SUD populations. Most positive protocols used left DLPFC stimulation and delivered ≥10 sessions. All outcomes were subjective, samples concentrated on methamphetamine and cocaine users, and long-term effects were poorly characterized. rTMS is promising for sleep in SUDs but requires objective sleep measures and diverse, controlled trials before routine adoption. 3