30-Second Takeaway
- An explainable XGBoost model reliably predicts textbook outcome after oral cancer free flap reconstruction (AUC **0.843**).
- Population-based pathogenic variant (PV) testing identifies high-risk women missed by clinical and polygenic risk stratification.
Week ending June 6, 2026
AI tools, personalized interventions, and genetic testing that shift perioperative and screening decisions
Explainable XGBoost predicts textbook outcome after free flap oral cancer reconstruction
In 752 single-center free flap reconstructions, textbook outcome occurred in 38.2% of patients. An XGBoost model achieved AUC 0.843, accuracy 0.764, sensitivity 0.733, and Brier score 0.152 on internal validation. Top predictors were albumin, age, operative time, tumor T stage, and neutrophil-to-lymphocyte ratio. SHAP analysis suggested actionable thresholds: age >50, albumin >45 g/L, and operative time >400 minutes for risk stratification.
Augmented reality improves technical performance for surgical novices
Systematic review of 11 studies (347 trainees) found AR improved objective technical metrics in most studies. Consistent benefits included error reduction and faster early learning, especially for novices in visuospatial tasks. An expertise-reversal effect occurred: diminishing returns for experienced surgeons. Heterogeneous methods, outcomes, and short follow-up limit conclusions about long-term retention and cost-effectiveness.
Protocol: AI-assisted education trial for older head and neck cancer patients
This single-center RCT will randomize 100 postoperative head and neck cancer patients aged ≥60 to AI-assisted versus standard SMS education for 12 months. Planned outcomes include mental health, social support, and multiple quality-of-life measures assessed at five timepoints. Analysis will use intention-to-treat linear mixed models to handle repeated measures and missing data. Generalisability is limited by single-center design and reliance on self-reported outcomes.
References
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Additional Reads
Optional additional studies from this edition.