Genetics

Visual arrays and behavioral nudges did not change Lynch syndrome risk estimates or sharing intentions

In a randomized online trial (n=1041), standard versus sequential icon arrays produced similar colorectal cancer risk estimates (60.36% vs 60.91%, p=0.58). A behavioral nudge in the communication frame did not increase intention to share genetic results with relatives (p=0.23). Effects were consistent across health literacy, education, prior testing, personal and family cancer history. 1

Dose-dependent multi-locus genetic burden strongly increases dementia risk in Parkinson’s disease

Meta-analysis of 24 cohorts (n=7745, 28,737 visits, 15 years) found dementia risk rose monotonically with number of progression loci. One locus conferred HR 1.56, two loci HR 3.21, and ≥3 loci HR 7.49 for dementia versus no loci. Individual loci (GBA1, APOE ε4, RIMS2, TMEM108, WWOX) associated with higher risk, but cohort heterogeneity was present. 2

Herbal medicine use and data‑protection concerns shape pharmacogenomics attitudes in British South Asians

Survey of 553 British South Asian adults found 66% used herbal remedies, commonly Black seed, turmeric, and ginger, which inhibit CYP2C9. Fifty‑eight percent were willing to provide DNA for PGx testing but 69% feared data misuse and 87% wanted stronger data protections. Herbal use correlated with lower reported medication adherence and higher perceived inefficacy and adverse reactions versus national comparators. 3