Gastroenterology

Rome/IOIBD consensus defines and guides management of IBD with IBS‑like symptoms

A multidisciplinary Rome Foundation/IOIBD panel endorsed the term “IBD with IBS‑like symptoms” for pain, bowel‑habit change, or bloating not explained by active inflammation. For clinical practice they recommend combining Rome clinical criteria with objective exclusion of inflammation before labeling this condition. They endorsed candidate research thresholds for endoscopic, histologic, biomarker, and imaging remission and listed appropriate therapies including psyllium, short‑term low FODMAP diet, targeted drugs, and brain‑gut behavioral therapies. This consensus standardizes evaluation and treatment to avoid unnecessary escalation of IBD therapy in patients without objective inflammation. 1

Framework for responsible LLM use in gastroenterology and hepatology

This review outlines governance, risk stratification, and legal considerations for deploying large language models in GI care. Key safeguards include human oversight, validation in representative populations, privacy protections, and continuous monitoring for hallucinations and bias. Actionable institutional checklists are provided to align LLM capabilities with clinical risk and regulatory requirements. The authors caution that LLMs are assistive tools, not independent medical decision‑makers. 2

Internet education improved IBS outcomes; added CBT or FODMAP modules provided no extra benefit

In a four‑arm RCT of 642 adults with IBS, responder rates at 3 months were similar across groups, 42.6%–45.1%, with no between‑group difference (OR 0.97, p=0.989). All groups, including general internet education alone, showed within‑group improvements in symptoms and quality of life. Adherence to the CBT and FODMAP modules was low (9–20%), which may explain the lack of additional benefit. Results suggest low‑intensity internet education can be effective, but module uptake is a barrier to additive effects. 3