Dermatology

Core outcome set (COS) of six domains recommended for facial aging trials

A Delphi process with patients and clinicians produced a 6-domain COS for facial aging trials. Required domains include convenience, time to return to normal activity, targeted-area assessment, effect duration, adverse-event severity, and patient satisfaction. The authors recommend reporting these domains to enable direct comparison and pooled analyses across interventions. Adoption should improve trial interpretability and facilitate meta-analyses of facial aging therapies. 1

Systematic review: digital health interventions show mixed QoL effects in dermatology

This systematic review of 14 studies grouped DHIs into telemedicine, targeted communication, tracking, and client-to-client support. Among 8 telemedicine studies, 6 reported noninferior or superior quality-of-life outcomes versus in-person care. Targeted client communication improved mental health and self-efficacy but showed mixed QoL results. Overall evidence is limited by heterogeneity, risk of bias, and short follow-up. 2

Dermatologist-performed TBSEs detect early skin cancer with higher yield in higher-risk groups

In 3,127 screening encounters, premalignant lesions were found in 11.0% and malignant lesions in 2.6% of exams. The overall number needed to biopsy was 4.83, improving from 6.10 to 2.79 across screening rounds. Detection was concentrated in older adults and those with prior nonmelanoma skin cancer. Results reflect voluntary participation and variable biopsy practices, so expect selection and ascertainment biases. 3