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Grand RoundsWeekly Evidence Brief

Anesthesiology

Edition
Latest

30-Second Takeaway

  • Intrathecal opioids give the largest 24‑hour opioid and pain reductions in adult cardiac surgery.
  • New persistent opioid use after surgery is common in opioid‑naïve US patients (pooled ~**7.15%**).

Latest - Week ending June 27, 2026

Five recent papers relevant to anaesthesia practice: trainee wellbeing, locoregional analgesia in cardiac surgery, anaesthetic choice and postoperative cognition, persistent opioid use after surgery, and social robots in

Rising early burnout and preference for less‑than‑full‑time training among UK anaesthesia trainees

BRITISH JOURNAL OF ANAESTHESIAJun 26, 2026

Baseline data from the 2024 UK trainee cohort show 76% prefer less‑than‑full‑time training at the start of specialty training. Trainees report high effort‑reward imbalance and greater stress compared with prior generations. Non‑anaesthetic ACCS rotations correlated with higher burnout and concerns about training bottlenecks were common. These findings should inform training bodies to create flexible, psychologically safe, and sustainable training pathways.

Network meta‑analysis: intrathecal opioids reduce 24‑hour opioids and pain most after cardiac surgery

REGIONAL ANESTHESIA AND PAIN MEDICINEJun 26, 2026

In 133 randomized trials (9,816 patients), intrathecal opioids reduced 24‑hour opioid use by -14.8 MME versus control. Intrathecal opioids also reduced 24‑hour pain by -1.2 cm on the VAS, the largest and most consistent effect. ESPB and PIPB produced smaller opioid reductions and may be reasonable when neuraxial techniques are contraindicated. Heterogeneity across trials was substantial, limiting certainty about comparative effectiveness and recovery outcomes.

Desflurane versus propofol in older adults: similar PND incidence but longer delirium duration with desflurane

BMC GERIATRICSJun 20, 2026

In 126 patients ≥65 undergoing major urological surgery, overall PND incidence did not differ between propofol and desflurane. Delirium‑present days were longer with desflurane (median 1.5 vs 1 days; P = 0.044). Interleukin‑6 rose in both groups and was higher on day 3 in patients who developed delirium. The longer delirium duration with desflurane is exploratory given few delirium events and requires cautious interpretation.

References

Numbered in order of appearance. Click any reference to view details.

Additional Reads

Optional additional studies from this edition.

Edition context

Clinical signal

  • Monitor and address trainee burnout and demand for less‑than‑full‑time training in workforce planning.
  • When neuraxial techniques are contraindicated, consider ESPB or PIPB as modest opioid‑sparing alternatives.
  • Expect substantial heterogeneity in NPOU estimates; prioritize multimodal and opioid‑sparing strategies.