Allergy & Immunology

Asthma and allergic burden linked to higher fracture and osteoporosis risk in older adults

In UK Biobank participants aged ≥60 followed for median 13.8 years, asthma associated with major osteoporotic fracture (HR 1.20, 95% CI 1.14–1.27). Asthma plus allergic rhinitis showed larger associations with fracture (HR 1.36) and hospital-recorded osteoporosis (HR 1.46). Allergic disease burden demonstrated a graded relation with both outcomes across sensitivity analyses. These are observational findings and do not establish causality; confirmatory studies are needed before changing guidelines. 1

Eight early features associate with mortality in ICU patients with grade 4 irAEs

In 26 ICU patients with grade 4 irAEs, triangulation identified eight early features consistently linked to mortality. Higher early lactate, vasopressor use, oxygen therapy, pneumonia, and higher neutrophil percentage correlated with higher mortality. Lower BMI and exposure to VEGF‑inhibitors were inversely associated with death in this cohort. This exploratory, very small study supports hypothesis generation and early risk stratification, not clinical prediction model deployment. 2

B‑cell research in allergy is growing with translational focus on tissue and regulatory subsets

A 20‑year bibliometric analysis (3,084 WoS articles, 71 PubMed trials) shows rising publications on B cells in allergic disease. Emerging hotspots include regulatory B cells, plasma cells, and tissue‑associated B‑cell biology. PubMed clinical‑trial records suggest increasing translational interest in B‑cell–directed interventions for allergy. The authors call for large multicenter studies with standardized B‑cell phenotyping to advance precision approaches. 3