Allergy & Immunology

Occupational irritants associated with fewer sIgE sensitizations in adult-onset asthma

In 924 adults from the EGEA cohort, occupational irritant exposure was associated with a lower number of sIgE sensitizations in participants with adult-onset asthma (adjusted mean ratio 0.63, p≈0.06). Irritant exposure was linked to reduced house dust mite and pollen/animal predominant sensitization profiles (p=0.02 and p=0.06 respectively). No association was observed in participants without asthma or with childhood-onset asthma, and longitudinal analysis in 271 children showed no 'healthy hire' effect. Findings suggest exposure may influence sensitization through non-immunological mechanisms rather than preventing childhood sensitization. 1

Psychiatric diagnoses correlate with higher documented allergy counts

Multicenter retrospective analysis of 71,725 adults found psychiatric diagnosis associated with more documented allergies (B = 0.74; R2 = 0.132; p < 0.001). Strongest associations were with somatic symptom, trauma-related, and obsessive-compulsive disorder categories. Authors highlight need for allergy verification in patients with psychiatric diagnoses to avoid mislabeling and unnecessary avoidance. 2

Accelerated one-strength HDM SCIT shows comparable systemic safety to standard regimen

In this randomized multicenter Chinese trial (n=211), systemic adverse drug reactions were similar between One-strength and Standard SCIT arms (7.4% vs 8.7%, p=0.72). Overall ADRs occurred in 57.3% of participants, mostly local and WAO grade 1–2, with no grade ≥3 events reported. Tolerability favored the One-strength regimen by patient and investigator ratings, but the open-label design may limit generalizability. 3